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Kudzu-Cardiovascular and Cognitive Function |
Specific Aims:
To test the hypothesis that the kudzu polyphenols are differentially distributed into body compartments more rapidly than soy isoflavones such as genistein.
To test the hypothesis that the ability of kudzu to reduce arterial pressure, stroke and cogniive dysfunction is related to hormonal-renal regulation, neural control of blood pressure and vascular dysfunction. Specifically to determine the safety and efficacy of dietary kudzu supplementation in SHR-SP and test the mechanisms underlying the beneficial effects.
To test the hypothesis that in ovariectomized, polyphenol-depleted, middle-aged SHR-SP, dietary kudzu preserves cardiovascular and cognitive function by altering signaling proteins related to the norepinephrine transporter and antioxidant regulators in the brain and vasculature.
Project Leader:
J. Michael Wyss Ph.D.
Co-Investigator:
Helen Kim Ph.D.
Roger C. White Ph.D.
Ning Peng Ph.D.
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